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In What Cases Should I Take Natural Thyroid Medications?

By Sleep Health Energy Team · · Updated

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In thyroid treatment, Natural Desiccated Thyroid (NDT) medications have become a point of discussion among healthcare providers and patients alike.

Unlike synthetic thyroid hormones, NDT thyroid medications are derived from the dried thyroid glands of animals, typically pigs, and contain both T3 (triiodothyronine) and T4 (thyroxine) hormones.

This article explains when NDT might be considered, plus its limits. It is general information, so decide on any change with your doctor.

Understanding NDT Thyroid Medications

NDT thyroid preparations have been used for over a century to treat hypothyroidism. They contain both T4 and T3, while the standard synthetic treatment, levothyroxine, contains only T4.

The American Thyroid Association notes that the balance of T4 and T3 in animal thyroid differs from the human thyroid, and the amounts can vary from batch to batch. For these reasons, levothyroxine remains the usual first choice, and NDT is prescribed less often today.

When to Consider NDT Thyroid Medications

Hypothyroidism with Inadequate Response to Levothyroxine

  • Many patients with hypothyroidism are initially treated with levothyroxine, a synthetic T4 hormone. However, some individuals continue to experience symptoms despite achieving normal TSH levels. NDT may be considered for patients who do not feel well on levothyroxine alone, as the addition of T3 might help alleviate residual symptoms.

Patients with Conversion Issues

  • Some individuals have difficulty converting T4 to the more active T3 hormone. NDT provides T3 directly, so some doctors try it for people with low T3 levels despite normal TSH and T4. The evidence that this helps is limited.

Preference for Natural Thyroid Hormone Replacement

  • Some patients prefer an animal-derived product. Keep in mind that the T4 in levothyroxine is chemically identical to human T4, and NDT tablets also contain binders, so they are not completely “natural.” NDT is an option only when it is medically appropriate and closely monitored.

T3 and T4 Balance Considerations

  • Patients who have not achieved symptom relief with synthetic T4 alone may benefit from the T3 and T4 combination found in NDT. However, NDT supplies a different T4-to-T3 balance than the human thyroid, which can make blood levels harder to keep stable.

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Benefits of NDT Thyroid Medications

Symptom Improvement

  • Some patients report that they feel better on NDT, especially in energy, mood and focus. Clinical trials have not consistently shown that it works better than levothyroxine.

Comprehensive Hormone Replacement

  • NDT includes both T3 and T4, which may suit certain individuals who do not do well on T4 alone.

Considerations and Cautions

Standardization and Dosing

  • One of the challenges with NDT medications is the potential variability in hormone concentrations between batches. It’s crucial to have regular follow-ups and blood tests to ensure thyroid levels remain within the desired range.

Side Effects and Risks

  • Just like synthetic thyroid medications, NDT can cause side effects if dosed improperly. Over-replacement can lead to symptoms of hyperthyroidism, including palpitations, anxiety and trouble sleeping, and over time it can contribute to bone loss and heart rhythm problems.

  • NDT should not be used during pregnancy, because its T3 does not reach the developing baby. Never buy thyroid “supplements” online to self-treat; dosing must come from your prescriber.

Medical Supervision Is Key

  • Deciding to use NDT should always be done under the guidance of a healthcare provider experienced in managing thyroid disorders. Close monitoring is essential to adjust dosing and ensure the medication is achieving its intended effect without causing adverse outcomes.

How to Start NDT Thyroid Medications

  1. Consultation with a Healthcare Provider: Discuss your symptoms, treatment history, and preferences with a provider who is knowledgeable about NDT.
  2. Comprehensive Thyroid Testing: Ensure a full thyroid panel is conducted, including TSH, Free T4, Free T3, and thyroid antibodies, to get a complete picture of your thyroid health.
  3. Gradual Transition: If switching from synthetic thyroid hormones to NDT, a gradual transition under medical supervision is often recommended to monitor response and adjust dosing accordingly.
  4. Regular Monitoring and Adjustment: Ongoing blood tests and symptom tracking are crucial for fine-tuning the dosage and ensuring the effectiveness of the treatment.

Natural Desiccated Thyroid medications offer an alternative for those seeking different options for managing thyroid conditions, particularly hypothyroidism.

While NDT may not be suitable for everyone, it could be a viable option for patients who have not found symptom relief with synthetic hormones alone, those with conversion issues, or individuals who prefer a natural hormone replacement strategy.

Approach NDT treatment with careful consideration, informed by a thorough evaluation and ongoing monitoring by a healthcare professional.

As with any medical treatment, the goal is to find the most effective and safe approach tailored to each individual’s health needs and circumstances.

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